Largest Career Margin Over 2nd Best

I guessed recently that Henderson's margin over Brock in stolen bases was the largest among all major baseball career records. Among the only ones I found with larger margins than Henderson's 49.9% margin, none would be considered "major":
134.8% Barry Bonds 688 intentional walks over 2nd highest total, 293
52.5% Nolan Ryan's 2795 walks allowed over 2nd highest total, 1833

The next-highest current margin on a major category is Cy Young's 22.5% margin over Walter Johnson in wins (511 to 417); although both Lee Smith in saves and Nolan Ryan in strike outs had margins of over 38% at one time in the last 15 years, before other competitors neared (Ryan) or surpassed (Smith) their totals.